Four transnational research consortia will be funded under the umbrella of the ERA-CVD JTC 2020. The total funding volume of the call amounts to about 3 M€.
Projects are shown below by alphabetical order:
Cardiovascular stress impacts on neuronal function: intracellular pathways to cognitive impairment
Coordinator: Jordi Garcia-Ojalvo, Pompeu Fabra University, Barcelona, Spain
- Angel Ois, Hospital del Mar, Barcelona, Spain
- Attila Gürsoy and Ozlem Keskin, Koc University, Istanbul, Turkey
- Raúl Vicente, University of Tartu, Estonia
- Stanley Nattel, Montreal Heart Institute, Canada
Cardiovascular disease is a known risk factor for the development of cognitive impairment and dementia as we age, but the reasons for this connection at the level of genes and proteins are still unclear. The goal of CardioStressCI is to identify proteins linked to both disorders, using cellular stress as a guide, with the ultimate goal of informing new diagnostic and treatment methods.
ENdothelial Retinal function as Indicator for vascular Cognitive Health
Coordinator: Ingeborg Stalmans, Research Group of Ophthalmology, Department of Neurosciences, KU Leuven, Leuven, Belgium
- Moti Freiman, Technion, Israel Institute of Technology, Department of Biomedical Engineering, Haifa, Israel
- Hélène Girouard, Montreal Heart Institute: Research Centre, Department of Surgery, Université de Montréal, Montréal, Canada.
- Cécile Duplaa, Inserm U1034, Université de Bordeaux, Bordeaux, France
- Henner Hanssen, Department Sport, Exercise and Health (DSBG), University of Basel, Basel, Switzerland
Microvascular dysfunction is a key player in cardiovascular diseases and precedes vascular dementia. This project aims to explore the potential of retinal parameters to detect and monitor microvascular dysfunction in the clinic as well as in the laboratory, making use of Artificial Intelligence. The final goal is to correlate these with cognitive decline in order to enable prevention of vascular neurodegeneration through early vascular screening via a simple exam of the eye.
Cerebrovascular-immune interfaces: searching for an immune signature coupling hypertension to cognitive dysfunction
Coordinator: Giuseppe Lembo, IRCCS Neuromed, Italy
- Pablo Blinder, Tel-Aviv University, Israel
- Turgay Dalkara, Hacettepe University, Turkey
- Tomasz Guzik, Jagiellonian University, Poland
- Slava Epelman, University Health Network, Canada
The ImmuneHyperCog consortium will investigate i) the mechanisms driving vascular cognitive impairment at the vascular-immune interface, ii) the immune landscape of the hypertensive brain and iii) the relationships between brain immunity and neuronal activity. Human studies and biobanks’ tissue will help in validating potential neuro-vascular-immune therapeutic targets to hamper vascular cognitive impairment.
Prevention of Vascular Cognitive Impairment through Early Detection of Cardiovascular Diseases
Coordinator: Philippe Boucher, UMR CNRS 7021, Strasbourg University, France
- Katey J Rayner, University of Ottawa Heart Institute, Canada
- Lina Badimon Maestro, Research Institute Hospital de la Santa Creu i Sant Pau-Autonomous University of Barcelona, Spain
Atherosclerosis and hypercholesterolemia and subsequent inflammation and oxidative stress are major causes of vascular cognitive impairment. In this proposal, our team will investigate how intracellular cholesterol trafficking, oxidative stress and inflammation, promote blood-brain barrier breakdown and affect cerebral blood flow, and search within these pathways for molecular targets with therapeutic potential to improve cerebrovascular function.