JTC 2016

JTC2016 (closed)

Heart failure

Facts and figures

Funded projects



Partner (Countries)

Summary (short)

Non myocyte interplay as a novel platform for mechanistic insights and therapeutic approaches in ACM heart failure

 Giulio Pompilio, Centro Cardiologico Monzino-IRCCS, Milan, Italy

Germany, France, Spain, Netherlands, Slovenia 

 Heart failure and life-threatening arrhythmias can be indicative of Arrhythmogenic Cardiomyopathy (ACM). In order to test potential therapeutics, this project exploits an innovative patient-derived cell model.
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Early detection and prevention of cardiac dysfunction and heart failure induced by cancer chemotherapeutics

Canan Nebigil, CNRS, University of Strasbourg, Strasbourg, France

France, Germany, Italy, Taiwan, Netherlands, Turkey

Anticancer treatments such as chemotherapy can cause heart failure. Minimising these harmful effects is the goal of the Cardio-Oncology project.
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Mechanisms of regenerative cardiomyocyte proliferation

Jeroen Bakkers, Hubrecht Institute, Utrecht, Netherlands

Germany, Israel, Italy

This project examines why zebrafish naturally regenerate cardiomyocytes while mice do not. Finding the difference might contribute to developing regenerative medicine strategies for humans with ischemic heart disease.
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Communication between cardiomyocytes and innate immune cells in failing hearts

Eva van Rooij, Hubrecht Institute, Utrecht, Netherlands

Germany, France

After myocardial damage the immune system plays an important part in cellular regenerative responses. CLARIFY investigates the communication between cardiac myocytes, cardiac stem cells and innate immune cells during ischemic heart failure.
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Determining the role of clinical and epigenetic risk markers in dilated cardiomyopathies and heart failure

Hugo A. Katus, University Hospital Heidelberg, Heidelberg, Germany

Estonia, France, Poland, Netherlands

Up to half of the cases of dilated cardiomyopathy can be explained by genetic predisposition. Exploring the precise mechanisms leading to these variations is what this project aims at.
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Exploring new pathways in age-related heart diseases

Thomas Thum, Hannover Medical School, Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover, Germany

Netherlands, Italy, Spain, France, Romania

EXPERT will identify pathways of age-related heart failure, and explore noncoding
RNA (ncRNA)-mediated regulatory pathways of the human genome.
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Heart Failure Rescue by Nutritional Approaches: relevance of mitochondrial substrate utilization

Borja Ibanez, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain

Italy, France

The project explores the potential of a high-fat diet as a therapy for dilated cardiomyopathy.
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Gene Profiling Test for Identification of Treatable Patients with Acute and Chronic Heart Failure

Heinz-Peter Schultheiss, Institute for Cardiac Diagnostics and Therapy (IKDT), Berlin, Germany

Germany, Italy, Spain

GENPROVIC seeks to establish a gene profile biomarker test in order to diagnose patients with virus-induced heart diseases.
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A prognostic marker of heart failure with impaired ejection fraction

Florence Pinet, Inserm1167, Institut Pasteur de Lille, University of Lille, Lille, Florence, France

Germany, Spain, Italy, Poland

The objective of this proposal is the development of the long noncoding RNA LIPCAR as a new
diagnostic and prognostic marker for heart failure (HF) patients.
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Targeted LYmphatic and MIcrovessel Treatments in metabolic-DISease HFpEF

Ebba Brakenhielm, INSERM, Rouen Institute for Research and Innovation in Biomedicine, France

The Netherlands, Poland, Belgium, Spain

Heart Failure with preserved Ejection Fraction (HFpEF) is one of the most prevalent kinds of heart disease. LYMIT-DIS examines the mechanisms involved in the cardiac diastolic dysfunction in HFpEF.
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Non-coding RNAs in cardiac macrophages and their role in heart failure

Stefan Engelhardt, Technische Universität München, Munich, Germany

Netherlands, Belgium

The MacroERA project analyses the microRNA portfolio of macrophages and their role in heart failure progression.
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Metabolic Therapy for Managing Diastolic Heart Failure

Simon Sedej, Medical University of Graz, Graz, Austria

Germany, Portugal, France,
Spain, Switzerland

The consortium tests whether caloric restriction mimetics prevent the development of diastolic dysfunction.
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Gene therapy with phosphodiesterases to treat heart failure

Rodolphe Fischmeister, INSERM and University Paris-Sud, Paris, France

Germany, Norway, Italy

Researchers test a new gene therapy to prevent or reverse heart failure.
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Novel RNA based therapies for treatment-resistant forms of severe cardiomyopathy caused by LMNA mutations

Yigal Pinto, University of Amsterdam, Amsterdam, Netherlands

France, Israel, Germany

A mutation in Lamin A/C can lead to treatment-resistant forms of severe cardiomyopathy. VARIATION explores novel RNA based therapies targeting the mutated allele.
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