Non myocyte interplay as a novel platform for mechanistic insights and therapeutic approaches in ACM heart failure


Giulio Pompilio
Centro Cardiologico Monzino-IRCCS, Milan, Italy

Carlo Gaetano, Goethe University, Frankfurt am Main, Germany
Angelo Parini, Institut des Maladies Métaboliques et Cardiovasculaires, INSERM, Toulouse, France
Josep Brugada Terradellas, Fundació Clínic per a la Recerca Biomèdica/Hospital Clínic, Barcelona, Spain
Christine Mummery, Leiden University Medical Centre, Leiden, the Netherlands
Bojan Vrtovec, University Medical Centre Ljubljana, Ljubljana, Slovenia

Research focus:
Arrhythmogenic Cardiomyopathy (ACM) is a genetic cardiac disease, mainly affecting young people and athletes, characterized by heart failure and life-threatening arrhythmias. This project will study the cardiac cell interplay and develop a platform to test potential therapeutics, by exploiting an innovative patient-derived cell model combining CMs from induced pluripotent stem cells, Stromal cells and Inflammatory mediators (CSI model). This project is expected to elucidate mechanisms underlying ACM pathogenesis and to identify new disease targets and potential therapeutics. Engagement activities towards patient associations and advocacy groups will explain why the project questions and outcomes are relevant to patients and caregivers.